Human PDGF

For long term storage, the product should be stored at lyophilized state at -20°C or lower. Human PDGF-BB, premium grade is a disulfide-linked homodimeric polypeptide chain containing 2×109 amino acids, and has a calculated MW of 12.4 kDa. The reducing protein migrates as a 14 kDa polypeptide and the non-reducing disulfide-linked homodimer migrates as a kDa protein. $65 Standard Overnight flat rate for as many products shipped within the United States. MACS® iQ View Software – sophisticated yet simple analysis of ultrahigh-content imaging dataComplete workflow solution for large-scale 3D fluorescence microscopyEvery scientific publication has its story.
Protein Concentrations Total  protein concentration 0.1 mg/ml after reconstitution. The above data is a representative example from a Eurofins DiscoverX cell-based assay that uses this ligand. Except human recombinant as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors.

Moreover, locally administered PDGF-BB and TCP (Augment®) have been investigated in acute wrist fractures and proved to support hindfoot and ankle fusions . Thus, supplementation of TCP with PDGF-BB is a favorable strategy in regenerative dentistry, orthopedics and traumatology. Useful for cell culture and for the study of signaling pathways.
The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Recombinant Human PDGF-BB (Catalog # 220-BB) stimulates cell proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner. Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). We limit citation information for polyclonal antibodies to articles published within the last 5 years because the supply of a particular polyclonal antibody preparation is limited.
Human PDGF-BB IS possesses the same properties as naturally occurring PDFG-BB. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. Over-expression of PDGF has been linked to several diseases such as atherosclerosis, fibrotic disorders and malignancies. Synthesis occurs due to external stimuli such as thrombin, low oxygen tension, or other cytokines and growth factors.

18Nabel EG, Plautz G, Nabel GJ. Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Photomicrographs of representative sections from arteries transfected with a reporter gene or a PDGF B gene at 1 , 2 , 4 , 7  , 14 , and 21 days after gene transfer. Sections were incubated in PBS containing a chromogenic substrate of 5-bromo-4-chloro-3-indolyl phosphate p-toluidine (1 mg/mL) and nitro blue tetrazolium chloride (1 mg/mL) for 19 hours.
Intimal and medial boundaries were determined by digital planimetry. Intimal and medial areas in each section were measured, and I/M area ratios from the four sections were averaged to derive an I/M area ratio for each artery. Targets of CAR-T Cell Therapy 50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process. SARS-CoV-2 Mutants Emerging VoCs, Omicron, Delta, Beta, Alpha mutants and so on, including RBD, S trimer, S1, NTD, NP, etc.

Fluorochrome staining revealed no visible changes in the pattern of bone formation in defects filled with TCP and DBBM, irrespective of PDGF-BB. Furthermore, supplementation with PDGF-BB did not influence biomaterial degradation. 3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer. The activity is calculated by the dose-dependent proliferation of BALB/c 3T3 indicator cells and is typically 1-3 ng/mL. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
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B, Expression of recombinant PDGF B mRNA in transfected porcine arteries. PCR was performed on mRNA from PDGF B arteries 4 days without and with RT, 21 days without and with RT, nontransfected carotid artery at 4 days without and with RT, water control , and PDGF plasmid control , both after RT. Platelet-derived growth factor-B is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality.